• Venture Capital Investments Fuel Innovation in Greater St. Louis

    May 29, 2018

    Venture capital (VC) investment in the St. Louis area has maintained momentum in 2017, with over $334 million invested in a total of 48 local start-ups. Investments spanned many industries, from Bioscience research firm Adarza to software developers like Hatchbuck and investment research firm Prattle Analytics.  Individual companies have continued to attract higher investments than in previous years. In addition, seven startups received investments of over $10 million and 18 startups received investments of $1 million or more (1).

    These investors recognize strengths in the St. Louis region, with local companies developing potentially transformative technologies.  For example, Adarza Biosystems, a life science company specializing in diagnostic technology based on “multiplex protein detection”, received $17 million from local investment firm River Vest (2).  Medical startup CardiaLen, which is developing a device for treating atrial fibrillation, received $978,500 in angel investor funding (4).

     Venture capital also plays a vital role in St. Louis’ growing agricultural technology sector.  NewLeaf Symbiotics, an agricultural technology company, received investments of $30 million from Monsanto Growth Ventures and S2G Ventures. (5) S2G highlighted NewLeaf’s innovation as a key factor in his firm’s decision, saying the company was “driving the sustainability revolution” with its groundbreaking research.

    Another emerging leader in the agtech field, Benson Hill Biosystems, raised $25 million for developing CropOS, a platform which “integrates crop data and analytics” to “unlock the global genetic potential of plants” (6, 7).

    VC investments in 2017 illustrate the dynamic nature of the regional economy, where technological innovation intersects with entrepreneurial vision.  Venture capital is not only contributing to the regional economy; it is building the future industrial base of the region.

    Numerous investment opportunities make St. Louis an ideal location for launching and growing a startup. The region benefits from a range of venture capital firms with expertise about specific industries; from SixThirty, a seed fund that assists financial technology startups (8), to RiverVest Ventures, which identifies emerging leaders in the biosciences industry (10).

    Angel investors also play an important role in the growth of start-up firms. Of 48 start-ups that received venture capital funding in 2017, 18, or 37.5%, were funded by the St. Louis Arch Angels, a group of accredited investors in the region. Seven new start-ups were funded by the Arch-Angels and 19 received follow-up investments, with three companies receiving $1million or more.

    Opportunities such as the Startup Connection Venture Showcase, and InvestMidwest (www.investmidwestforum.com) give entrepreneurs the chance to secure early-stage investments (11). Over the last 17 years, InvestMidwest, an annual venture capital conference supported by the Regional Chamber, has raised over $1 billion for Midwestern companies.

    Just as importantly, St. Louis startups have increasingly drawn the attention of national investors. MediBeacon, a startup developing diagnostic devices, raised $11 million in funding from New York-based venture capital firm HC2 (12, 13). The region’s largest venture capital investment in 2016 was secured by Veran Medical Technologies, which received $31 million from Washington D.C.-based firm Oxford Finance (14). This funding enabled further development of the SPiN Thoracic Navigation System, a software designed to allow more efficient diagnoses of lung cancer (15).

    Between 2013 and 2016, companies in the St. Louis metro area raised over $1.3 billion in venture capital, or an average of $325 million per year. Startup companies raised these funds over almost 400 separate investments, with 2015 setting a record of 133 investments in 117 individual companies. The total value of those investments remained high, at $334 million, in 2017, although the number of investments decreased to 52. There has been a national trend towards fewer, more high-value investments over time. The St. Louis economy generally aligns with this national trend.

    As local companies fuel innovation, it’s no surprise that the St. Louis region is gaining national recognition by venture capital firms and industry leaders.


    (1) “St. Louis MSA Venture Capital Investments 2017” St. Louis Regional Chamber, May 11, 2018.

    (2) “About Us” Adarza Biosystems 2018.

    (3) “Adarza Biosystems Closes on $17 Million Series C Financing” Adarza Biosystems, Jan. 19, 2017.

    (4) “An Innovative solution in a world of ineffective stopgaps” Cardialen: Therapy, 2016.

     (5) “St. Louis Crop Science company raises $30 million” St. Louis Business Journal, Sept. 7, 2017.

    (6) “Press Release: Benson Hill Bisystems Closes $25M Series B Financing” Benson-Hill Biosystems, March 28, 2017.

    (7) “Benson Hill adds investors in $25 million financing round” St. Louis Business Journal: Technology, March 28, 2017.

    (8) “About SixThirty” SixThirty 2018.

    (9) “RiverVest leads $17 million investment in Adarza, brings on new President” St. Louis Business Journal: Technology, Jan. 19, 2017.

    (10) “60 startups that will pitch at Venture Showcase” St. Louis Business Journal: Technology Oct. 23, 2017.

    (11) “What is Startup Connection?” Startup Connection, 2015.

    (12) “New York firm invests another $10 million in MediBeacon” St. Louis Business Journal March 27, 2017.

    (13) “MediBeacon History” MediBeacon 2018.

    (14) “Veran raises $31 million from East Coast private equity firm” St. Louis Business Journal: Healthcare, Dec. 27, 2016.

    (15) “How it works” and “Benefits”, Veran Medical Technologies 2018.


  • St. Louis Region is 21st Largest in U.S. – Now What?

    Mar 23, 2018
    This past Thursday, the U.S. Census Bureau released its latest population estimates for the nation’s largest metropolitan areas. While we did grow as a region, our rate of growth was slower than those in other metro regions like Denver, Tampa and even Baltimore. As a result, we moved to the 21st largest metro area. But let’s be clear - we are doing well in a lot of areas. This story is not about urban vs. rural, this suburb vs. that suburb. Every metropolitan region across the country is competing for people, jobs and economic opportunities.

    The past two weeks, we beat out Louisville, Kansas City and Milwaukee to win over 2,200 new jobs with companies like Amazon, Cenlar and Grove Collaborative. Our startup businesses continue to grow and thrive. Just this month, Chamber staff are meeting with business leaders in Dallas, Cleveland, Chicago and New York who are interested in locating in our region. People, jobs and companies are moving to St. Louis, but the more economic opportunities we can provide – both in terms of jobs and a talented workforce – the more likely we can grow at a faster rate.

    The core mission of the St. Louis Regional Chamber is regional economic development. That means when a business is looking to relocate its business, we look at all corners of the region – City of St. Louis, St. Louis County, St. Charles County, Madison County, St. Clair County, and beyond. Each area has its unique assets, and combining our strengths creates a region that has that is very competitive. Companies and business site consultants tell us they love the St. Louis region’s affordability, our strong talent in biosciences, financial sectors and healthcare, and our friendly business climate. According to the St. Louis Federal Reserve, we rank No. 7 in the country for adjusted real personal income per capita, 12 percent higher than the national average. This translates into a very affordable cost of living and doing business. These are very real reasons why companies choose to do business in St. Louis and we think many more will, especially as the Chamber and community partners continue to work with regional educational partners and employers to grow and develop our workforce. 

    It is important that we also work together to attract new people to St. Louis who want to enjoy a low cost of living, great family amenities, and a chance to make a better life for themselves and their companies than in high-cost areas of the country. We will continue to work hard with our partners in both Illinois and Missouri to market the region around the country and across the world. 

    Ultimately, people and businesses are looking for economic opportunities. That is how we in St. Louis will grow. We must continue to work together to bring more jobs, build up our workforce, and attract talented and innovative people to the St. Louis region. We should support people and organizations that make St. Louis a better place to live. That is the call to action we should take from this. We have many assets, we are open for business, and it is time we tell a new story about St. Louis.