Much has changed at the St. Louis Regional Chamber since we were founded in 1836. Our name has changed, our headquarters has moved throughout downtown St. Louis, and our priorities have shifted to mirror the issues of the time. However, our core mission has always been to convene like-minded business professionals and serve as a catalyst for the regional economy.

“The Chamber of Commerce and the organizations that followed, by whatever name, have been a real force for progress. That force must continue, for many challenges lie ahead. May our success meet those future challenges as successfully as our predecessors did the past ones.” – Former Chamber President James O’Flynn, served 1978 – 1986.

View our history timeline.